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Chen and colleagues conducted a large meta-analysis on the effects of omega-3 fatty acids DHA and EPA on all-cause mortality (Chen et al., 2016). They included 11 prospective studies, with a total of 371 965 general population participants. In these studies, a total of 31 185 deaths occurred. Using a random-effects model, relative risks of all-cause death were calculated in the included studies where omega-3 fatty acids were a topic of investigation. They found that dietary and circulating omega-3 fatty acids were associated with a reduced risk of all-cause mortality, with similar effect power for EPA and DHA. Expanding on this, a dose-response analysis was carried out to determine the effect strength of omega-3 dosage in relation to reduced all-cause mortality risk. This analysis showed that for every increase of 1% of circulating DHA in relation to the total amount of circulating fatty acids, a 21% decreased risk of all-cause mortality is realized.
Click on the file below to download the publication by Chen and colleagues Reference: Chen, G.-C., Yang, J., Eggersdorfer, M., Zhang, W., & Qin, L.-Q. (2016). N-3 long-chain polyunsaturated fatty acids and risk of all-cause mortality among general populations: A meta-analysis. Scientific Reports, 6(1), 28165. https://doi.org/10.1038/srep28165 |
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| Chen et al., (2016): N-3 long-chain polyunsaturated fatty acids and risk of all-cause mortality among general populations |
